It was great to find this site because I have a variety of symptoms I believe to be die-off. I am (at long last) addressing my candida/leaky gut/food allergy issues as I desire to be healthy again for another pregnancy. I initially went with Candidase, an enzyme based treatment, expecting little die off. Boy was I wrong! The recommended dose was too much for me and I had to quit completely. Also, I was not eliminating well which I think made it worse. So I tried another route. I decided to try Oxypowder by GHC. First 5 days were great and I was beyond "regular" for a change. Then, I began to get constipated, gassy, hives, red & itchy eyes and tingling in my extremities. I didn't think it was possible because I thought this was simply a colon flush, but seems that I am again struggling with die off. I am going to back down the dose but I don't want to quit. Like many, though, I am finding myself trying different things by trial and error and spending money I do not have! Also I am quite sad and disappointed this is taking a lot longer than anticipated... :( Just wondering if you had any advice. Thank you!!!